肿瘤细胞治疗研究
英文原题：FDG PET/CT of Atypical Myeloid Sarcoma After CAR T-Cell Therapy.
病灶在完成治疗后1.5个月出现。
一名23岁男性，既往有Ph-Like B细胞急性淋巴细胞白血病（B-ALL）伴JAK2重排病史，因1周内出现无数皮肤病变就诊。就诊前，其B-ALL多次复发，并接受了自体UCD-19嵌合抗原受体（CAR）T细胞治疗。病变在治疗完成后1.5个月出现。活检显示新发髓系肉瘤（MS），而B-ALL持续缓解。18 F-FDG PET/CT显示大量明显高代谢软组织病变，位于皮肤和皮下组织、肌肉、骨结构、黏膜、胸膜、纵隔、腹膜、腹膜后和睾丸。
A 23-year-old man with a history of Ph-Like B-cell acute lymphoblastic leukemia (B-ALL) with JAK2 rearrangement presented with innumerable skin lesions developing over 1 week. Before presentation, he had multiple relapses of his B-ALL and underwent autologous UCD-19 chimeric antigen receptor (CAR) T-cell therapy. Lesions appeared 1.5 months after completion of therapy. Biopsies showed new onset myeloid sarcoma (MS), with continued remission of B-ALL. 18 F-FDG PET/CT showed numerous markedly hypermetabolic soft tissue lesions located in the skin and subcutaneous tissues, muscles, osseous structures, mucosa, pleura, mediastinum, peritoneum, retroperitoneum, and testes.
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