肿瘤细胞治疗研究
英文原题：Pseudoprogression in CAR-T cell therapy for solid tumor: Case report.
我们报道了一例晚期胃癌老年患者在接受嵌合抗原受体（CAR）-T细胞治疗后出现假性进展。
我们报道了一例晚期胃癌老年患者在接受嵌合抗原受体（CAR）-T细胞治疗后出现假性进展。CAR-T细胞输注后1个月，肝转移灶增大，随后1个月通过计算机断层扫描发现病灶缩小。基于包括影像学、病理学、血清肿瘤标志物和临床症状的综合评估，我们诊断为CAR-T细胞治疗后的假性进展，此前研究尚未报道过这种情况。在本报告中，我们详细描述了患者的临床表现、影像学发现、治疗过程和随访结果。我们认为该病例对CAR-T细胞治疗研究具有重要意义，并为临床实践提供了有价值的见解。
We reported the pseudoprogression in an elderly patient with advanced gastric cancer after chimeric antigen receptor (CAR)-T cell therapy. The hepatic metastases enlarged 1 month after CAR-T cell infusion and then shrunk the next month as seen through computed tomography scanning. Based on a comprehensive evaluation that includes imaging, pathology, serum tumor markers, and clinical symptoms, we arrived at a diagnosis of pseudoprogression after CAR-T cell therapy, which has not been reported in previous studies. In this report, we provide detailed descriptions of the patient's clinical presentation, imaging findings, treatment process, and follow-up outcomes. We believe that this case holds important implications for CAR-T cell therapy research and offers valuable insights for clinical practice.
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