帕博利珠单抗联合二甲双胍治疗转移性头颈部癌的 II 期可行性研究
A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer.
二甲双胍联合帕博利珠单抗耐受性良好，仅出现轻度胃肠道不良事件，并展现出有前景的活性，值得在随机试验中进一步研究。
98.5分
★★★★★
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
HPV 相关恶性肿瘤治疗的潜在治疗靶点
英文原题：Potential Therapeutic Targets for the Treatment of HPV-Associated Malignancies.
研究概要
本综述文章旨在广泛总结HPV相关癌症治疗的最新进展，包括宫颈癌和头颈部鳞状细胞癌。
中文摘要
这篇综述文章旨在广泛总结HPV相关癌症（包括宫颈癌和头颈部鳞状细胞癌）治疗的最新进展。文章讨论了针对关键HPV E6和E7癌蛋白的相对较新疗法，包括使用TALENs和CRISPR/Cas9的基因编辑。鉴于HPV相关疾病具有增强的免疫原性，其他疗法如PRR激动剂、过继细胞转移和肿瘤疫苗正进入临床试验阶段。由于HPV致癌作用的机制、免疫原性和可逆性，HPV相关癌症为当前和未来的疗法提供了独特的靶点。
展开英文摘要原文
This review article aims to summarize broadly recent developments in the treatment of HPV-associated cancers, including cervical cancer and head and neck squamous cell carcinoma. Relatively new treatments targeting the key HPV E6 and E7 oncoproteins, including gene editing with TALENs and CRISPR/Cas9, are discussed. Given the increased immunogenicity of HPV-related diseases, other therapies such as PRR agonists, adoptive cell transfer, and tumor vaccines are reaching the clinical trial phase. Due to the mechanism, immunogenicity, and reversibility of HPV carcinogenesis, HPV-related cancers present unique targets for current and future therapies.
论文信息
- 作者
- Lu Z、Haghollahi S、Afzal M
- 单位
- Dartmouth Cancer Center, Manchester, NH 03104, USA.United Kingdom
- 文献类型
- 综述
- 期刊
- Cancers2024 Oct 14
- 原文标识
- PubMed 39456568 · DOI 10.3390/cancers16203474