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GD2 靶抗原与 CAR T 细胞:探戈是否不止需要两人

英文原题:GD2 Target Antigen and CAR T Cells: Does It Take More Than Two to Tango?

PubMed 2024/08/15(内容时间) Clin Cancer Res Q1 · IF 10.9(JCR 2025)

研究概要

过去十年中,CAR-T 细胞已成为部分血液系统恶性肿瘤的突破性癌症疗法。

中文摘要

过去十年,CAR-T 细胞已成为治疗部分血液系统恶性肿瘤的突破性疗法。将该疗法的成功转化至实体瘤治疗仍具挑战。本期文章讨论了可能有助于提高 CAR T 细胞治疗实体瘤疗效的策略。参见 Fischer-Riepe 等人相关文章,第 3564 页。

展开英文摘要原文

Over the past decade, chimeric antigen receptor T cells have emerged as a breakthrough cancer therapy in selected hematologic malignancies. Translating the success of this therapy to solid tumors is challenging. In this issue, we discuss strategies potentially useful to increase the chimeric antigen receptor T-cell efficacy in this clinical indication. See related article by Fischer-Riepe et al., p. 3564.

论文信息

作者
Locatelli F、Quintarelli C
单位
Department of Hematology/Oncology, Cell and Gene Therapy - IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.Italy
期刊
Clinical cancer research : an official journal of the American Association for Cancer Research2024 Aug 15
原文标识
PubMed 38869449 · DOI 10.1158/1078-0432.CCR-24-0486