肿瘤细胞治疗研究
英文原题：Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms.
γδ T 细胞对免疫应答的贡献与干扰素-γ（IFN-γ）的快速分泌相关。
γδ T 细胞对免疫应答的贡献与干扰素-γ（IFN-γ）的快速分泌相关。在此，我们展示了一个围产期胸腺波次的固有 IFN-γ 产生型 γδ T 细胞，其表达 CD8αβ 异二聚体，并在感染和癌症的临床前模型中扩增。CD8αβ + γδ T 细胞的最佳发育由低 T 细胞受体信号指导，并通过提供白细胞介素（IL）-4 和 IL-7 实现。该细胞群体具有病理相关性，因为在两种 T 细胞肿瘤小鼠模型中，过度活跃或组成性的 IL-7R-STAT5B 信号促进 CD8αβ + γδ T 细胞在胸腺和外周淋巴器官中的超生理积累。同样，CD8αβ + γδ T 细胞定义了人类 T 细胞急性淋巴细胞白血病儿科患者的一个独特亚群。本研究描述了 CD8αβ + γδ T 细胞的正常和恶性发育，这些细胞在生命早期富集，并参与对感染和癌症的固有 IFN-γ 应答。
The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and expand in preclinical models of infection and cancer. Optimal CD8αβ + γδ T cell development is directed by low T cell receptor signaling and through provision of interleukin (IL)-4 and IL-7. This population is pathologically relevant as overactive, or constitutive, IL-7R-STAT5B signaling promotes a supraphysiological accumulation of CD8αβ + γδ T cells in the thymus and peripheral lymphoid organs in two mouse models of T cell neoplasia. Likewise, CD8αβ + γδ T cells define a distinct subset of human T cell acute lymphoblastic leukemia pediatric patients. This work characterizes the normal and malignant development of CD8αβ + γδ T cells that are enriched in early life and contribute to innate IFN-γ responses to infection and cancer.
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