肿瘤细胞治疗研究
英文原题：Extramedullary relapse of multiple myeloma presenting as space-occupying lesion in liver treated with daratumumab, pomalidomide, dexamethasone and bendamustine.
多发性骨髓瘤（MM）患者的髓外复发通常与生化反应丧失和骨髓中出现可测量残留病灶相关。
多发性骨髓瘤（MM）患者的髓外复发常与生化反应丧失及骨髓中出现可测量残留病灶相关。发热是MM不常见的起病表现。对于在接受蛋白酶体抑制剂、抗CD38单克隆抗体和免疫调节药物治疗期间出现疾病进展的患者，其髓外复发的治疗具有挑战性，因为获得CAR-T 细胞和双特异性抗体的机会有限。我们报告一例以发热和模拟肝细胞癌的肝脏占位性病变为表现的复发性MM病例。在本病例报告中，我们还介绍了使用包含Dara-Pom-Benda-Dexa（daratumumab、pomalidomide、dexamethasone和bendamustine）的新型联合方案治疗复发性MM的经验。
Extramedullary relapse in patients with multiple myeloma (MM) is often associated with loss of biochemical response and the appearance of measurable residual disease in the bone marrow. Fever is an unusual presenting manifestation of MM. Treatment of extramedullary relapse in patients progressing on proteasome inhibitors, anti-CD38 monoclonal antibodies and immunomodulatory drugs is challenging, as access to chimeric antigen receptor T-cells and bispecific antibodies is limited. We report a case of relapsed MM who presented with fever and hepatic space-occupying lesion mimicking hepatocellular carcinoma. In this case report, we also present our experience of using a novel combination regimen comprising Dara-Pom-Benda-Dexa (daratumumab, pomalidomide, dexamethasone and bendamustine) for relapsed MM.
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