肿瘤细胞治疗研究
英文原题：Vaccination of Adults With Cancer: ASCO Guideline.
Vaccination of Adults With Cancer: ASCO Guideline.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
共纳入 102 篇文献进行系统评价：24 篇系统评价、14 项 RCT 和 64 项非随机研究。最大的证据体涉及 COVID-19 疫苗。推荐：接种疫苗的目标是限制感染的严重程度，并在可行的情况下预防感染。优化疫苗接种状态应被视为癌症患者照护的关键要素。该方法包括在患者首次就诊时记录疫苗接种状态；及时提供推荐的疫苗；以及在造血干细胞移植、CAR-T 细胞治疗或 B 细胞清除治疗后进行适当的再接种。需要医疗保健提供者之间积极互动和协调，包括初级保健从业者、药剂师和护理团队成员。家庭接触者接种疫苗将增强对癌症患者的保护。癌症患者的一些疫苗接种和再接种计划可能受到基础免疫状态和所接受抗癌治疗的影响。
为实体瘤或血液系统恶性肿瘤成人患者接种疫苗提供指导。
一项系统性文献综述识别了关于成人癌症患者或其家庭接触者所使用疫苗的有效性和安全性的系统性综述、随机对照试验（RCT）及非随机研究。本综述基于2013年美国感染病学会的指南。检索了PubMed和Cochrane图书馆，时间范围从2013年1月1日至2023年2月16日。ASCO召集了一个专家小组，对证据进行审查并制定推荐意见。
共纳入102篇文献进行系统评价：24篇系统评价、14项RCT和64项非随机研究。最大的证据体涉及COVID-19疫苗。推荐：接种疫苗的目标是限制感染的严重程度，并在可行的情况下预防感染。优化疫苗接种状态应被视为癌症患者照护的关键要素。该方法包括在患者首次就诊时记录疫苗接种状态；及时提供推荐的疫苗；以及在造血干细胞移植、CAR-T 细胞治疗或B细胞清除治疗后进行适当的再接种。需要医疗保健提供者之间积极互动和协调，包括初级保健从业者、药剂师和护理团队成员。家庭接触者接种疫苗将增强对癌症患者的保护。癌症患者的一些疫苗接种和再接种计划可能受到基础免疫状态和所接受抗癌治疗的影响。因此，疫苗策略可能与一般健康成年人群的疫苗推荐不同。更多信息可在www.asco.org/supportive-care-guidelines获取。
To guide the vaccination of adults with solid tumors or hematologic malignancies.
A systematic literature review identified systematic reviews, randomized controlled trials (RCTs), and nonrandomized studies on the efficacy and safety of vaccines used by adults with cancer or their household contacts. This review builds on a 2013 guideline by the Infectious Disease Society of America. PubMed and the Cochrane Library were searched from January 1, 2013, to February 16, 2023. ASCO convened an Expert Panel to review the evidence and formulate recommendations.
A total of 102 publications were included in the systematic review: 24 systematic reviews, 14 RCTs, and 64 nonrandomized studies. The largest body of evidence addressed COVID-19 vaccines. RECOMMENDATIONS: The goal of vaccination is to limit the severity of infection and prevent infection where feasible. Optimizing vaccination status should be considered a key element in the care of patients with cancer. This approach includes the documentation of vaccination status at the time of the first patient visit; timely provision of recommended vaccines; and appropriate revaccination after hematopoietic stem-cell transplantation, chimeric antigen receptor T-cell therapy, or B-cell-depleting therapy. Active interaction and coordination among healthcare providers, including primary care practitioners, pharmacists, and nursing team members, are needed. Vaccination of household contacts will enhance protection for patients with cancer. Some vaccination and revaccination plans for patients with cancer may be affected by the underlying immune status and the anticancer therapy received. As a result, vaccine strategies may differ from the vaccine recommendations for the general healthy adult population vaccine.Additional information is available at www.asco.org/supportive-care-guidelines.
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