肿瘤细胞治疗研究
英文原题：Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma.
胶质母细胞瘤（GBM）仍是一种致命的肿瘤。
胶质母细胞瘤（GBM）仍是一种致命的肿瘤。已知放化疗和皮质类固醇治疗会损害淋巴细胞的功能，可能影响自体CAR T细胞疗法的开发。我们在此对自体抗GD2 CAR T细胞进行了临床前研究，测试其针对GBM原代细胞的2D和3D模型的效果。我们检测到强大的抗肿瘤效果，突显了为GBM患者开发基于自体抗GD2 CAR T细胞疗法的可行性。
Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust antitumor effect, highlighting the feasibility of developing an autologous anti-GD2 CAR T cell-based therapy for GBM patients.
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