肿瘤细胞治疗研究
英文原题：Role of Immunotherapy in Sarcomas.
肉瘤是一组起源于间充质的恶性肿瘤，包含大量亚型。
肉瘤是一组间充质来源的恶性肿瘤，包含大量亚型。鉴于各种亚型的极大异质性以及该疾病的罕见性，肉瘤的治疗一直具有挑战性，患者预后较差。手术、放疗和化疗仍然是肉瘤患者治疗的基石。免疫治疗的引入彻底改变了各种实体和血液系统恶性肿瘤的治疗。在这篇综述中，我们讨论免疫治疗的基础知识和肉瘤中的免疫微环境；各种免疫治疗方式，如免疫检查点阻断、溶瘤病毒、癌症靶向抗体、疫苗治疗；以及过继性细胞疗法，如 CAR T 细胞疗法、T 细胞疗法和 TCR 疗法。
Sarcomas are a group of malignancies of mesenchymal origin with a plethora of subtypes. Given the sheer heterogeneity of various subtypes and the rarity of the disease, the management of sarcomas has been challenging, with poor patient outcomes. Surgery, radiation therapy and chemotherapy have remained the backbone of treatment in patients with sarcoma. The introduction of immunotherapy has revolutionized the treatment of various solid and hematological malignancies. In this review, we discuss the basics of immunotherapy and the immune microenvironment in sarcomas; various modalities of immunotherapy, like immune checkpoint blockade, oncolytic viruses, cancer-targeted antibodies, vaccine therapy; and adoptive cell therapies like CAR T-cell therapy, T-cell therapy, and TCR therapy.
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