肿瘤细胞治疗研究
英文原题：CAR-T cell therapy: a game-changer in cancer treatment and beyond.
近年来，癌症已成为主要死亡原因之一，全球每年约有1000万人死亡。
近年来，癌症已成为全球主要死亡原因之一，每年约导致1000万人死亡。最先进的嵌合抗原受体（CAR）T细胞免疫疗法已被证明是一种有前景的癌症治疗方法。CAR-T细胞疗法涉及对从患者血液中获取的T细胞进行基因改造，然后回输给患者。CAR-T细胞免疫疗法已显著提高血液系统恶性肿瘤的缓解率。CAR-T细胞疗法目前仅限于血液系统恶性肿瘤，目前正在努力开发额外的CAR构建体，如双特异性CAR、串联CAR、抑制性CAR、联合抗原、CRISPR基因编辑和纳米颗粒递送。随着这些进展，CAR-T细胞疗法有望改善传统癌症治疗（如化疗和放疗），同时减少相关毒性。本综述涵盖了CAR-T细胞免疫疗法的最新进展和优势。
In recent years, cancer has become one of the primary causes of mortality, approximately 10 million deaths worldwide each year. The most advanced, chimeric antigen receptor (CAR) T cell immunotherapy has turned out as a promising treatment for cancer. CAR-T cell therapy involves the genetic modification of T cells obtained from the patient's blood, and infusion back to the patients. CAR-T cell immunotherapy has led to a significant improvement in the remission rates of hematological cancers. CAR-T cell therapy presently limited to hematological cancers, there are ongoing efforts to develop additional CAR constructs such as bispecific CAR, tandem CAR, inhibitory CAR, combined antigens, CRISPR gene-editing, and nanoparticle delivery. With these advancements, CAR-T cell therapy holds promise concerning potential to improve upon traditional cancer treatments such as chemotherapy and radiation while reducing associated toxicities. This review covers recent advances and advantages of CAR-T cell immunotherapy.
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