决定异体 CAR T 细胞排斥与扩增的细胞和分子机制
Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
我们评估了11例接受单一批次cemacabtagene ansegedleucel(cema-cel)治疗的大B细胞淋巴瘤患者,cemacabtagene ansegedleucel是一种异体抗CD19 CAR T产品。
英文原题:New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat.
New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat.
嵌合抗原受体(CAR)T 细胞免疫疗法已彻底改变了一些晚期癌症的治疗,但其成功取决于能否确定正确的细胞表面靶点。
嵌合抗原受体(CAR)T细胞免疫疗法已革新部分晚期癌症治疗,但成功的前提是找到正确的细胞表面靶点。在一篇近期发表的文章中,作者利用癌症干细胞表面抗原CD133开发CAR-T疗法治疗脑转移瘤。参见Kieliszek等人的相关文章,第554页。
Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized cancer therapy for some advanced cancers, but success is predicated on identifying the correct cell surface target. In a recent article, the authors leveraged the cancer stem cell surface antigen CD133 to develop a CAR-T therapy for brain metastasis. See related article by Kieliszek et al., p. 554.
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