肿瘤细胞治疗研究
英文原题：Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders.
Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders.
淋巴瘤是一组异质性病理，由淋巴细胞克隆性增殖引起。
淋巴瘤是一组由淋巴细胞克隆性增殖引起的异质性病理实体。它们被分为霍奇金淋巴瘤和非霍奇金淋巴瘤；后者由B细胞、T细胞或NK细胞发生恶性转化而形成。人们认为饮食可以调节细胞氧化还原状态，而氧化应激通过作用于多种生物学机制参与淋巴瘤的发生；事实上，氧化应激可通过激活多种转录因子产生慢性炎症状态，从而增加促炎细胞因子的产生，并导致B淋巴细胞在抗体产生过程中受到过度刺激以及细胞DNA可能发生改变。我们工作的目的是探讨关于淋巴瘤、氧化应激和饮食之间可能相互作用的体外和体内研究结果。评估了多种饮食方案以及通过饮食摄入的可能具有抗氧化和抗增殖作用的物质。讨论了将营养保健品用作新型抗癌药物的可能性；尽管在淋巴瘤治疗中使用天然物质是一个有趣的研究领域，但在将其引入临床实践之前，还需要进一步研究以确定不同营养保健品的疗效。
Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice.
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