肿瘤细胞治疗研究
英文原题：Immunotherapy for Acute Myeloid Leukemia: Current Trends, Challenges, and Strategies.
AML的免疫治疗面临重大挑战，但新型策略正在研发中。
过去十年，B细胞淋巴系统恶性肿瘤和多发性骨髓瘤的免疫治疗取得了重大突破，但急性髓系白血病（AML）的进展则要少得多。然而，挑战催生创新，目前有几种治疗策略正在研究中。总结：在这篇综述中，我们回顾了AML免疫治疗的最新进展，包括靶向CD33和CD123的药物、免疫检查点抑制以及过继性细胞治疗策略。我们还分享了处理日益增多的研究性AML免疫疗法的概念框架，并提出了该领域的未来方向。
BACKGROUND: In the past decade, there have been significant breakthroughs in immunotherapies for B-cell lymphoid malignancies and multiple myeloma, but progress has been much less for acute myeloid leukemia (AML). Nevertheless, challenge begets innovation and several therapeutic strategies are under investigation. SUMMARY: In this review, we review the state of the art in AML immunotherapy including CD33- and CD123-targeted agents, immune checkpoint inhibition, and adoptive cell therapy strategies. We also share conceptual frameworks for approaching the growing catalog of investigational AML immunotherapies and propose future directions for the field. KEY MESSAGES: Immunotherapies for AML face significant challenges but novel strategies are in development.
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