肿瘤细胞治疗研究
英文原题：Epstein‒Barr virus-associated cellular immunotherapy.
已证实超过90%的人群终生潜伏感染EBV。
EBV 是一种人类疱疹病毒，可通过唾液传播，且普遍无症状。已证实超过 90% 的人群终生潜伏感染 EBV。EBV 可导致多种相关癌症，如鼻咽癌、弥漫大 B 细胞淋巴瘤和 Burkitt 淋巴瘤。目前，许多临床研究已证明，EBV 特异性细胞毒性 T 淋巴细胞及其他细胞疗法可安全有效地输注，以预防和治疗 EBV 引起的某些疾病。本综述将主要聚焦于讨论 EBV 特异性细胞毒性 T 淋巴细胞，并简要涉及治疗性 EBV 疫苗和CAR-T 细胞疗法。
Epstein‒Barr virus (EBV) is a human herpes virus that is saliva-transmissible and universally asymptomatic. It has been confirmed that more than 90% of the population is latently infected with EBV for life. EBV can cause a variety of related cancers, such as nasopharyngeal carcinoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Currently, many clinical studies have demonstrated that EBV-specific cytotoxic T lymphocytes and other cell therapies can be safely and effectively transfused to prevent and treat some diseases caused by EBV. This review will mainly focus on discussing EBV-specific cytotoxic T lymphocytes and will touch on therapeutic EBV vaccines and chimeric antigen receptor T-cell therapy briefly.
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