肿瘤细胞治疗研究
英文原题：Diagnosis and management of post-transplant lymphoproliferative disease following solid organ transplantation in children, adolescents, and young adults.
Diagnosis and management of post-transplant lymphoproliferative disease following solid organ transplantation in children, adolescents, and young adults.
移植后淋巴增殖性疾病（PTLD）仍然是儿童实体器官移植（SOT）的主要并发症。
移植后淋巴增殖性疾病（PTLD）仍然是儿童实体器官移植（SOT）后的主要并发症。大多数为EBV驱动的CD20+ B细胞增殖，对减少免疫抑制和抗CD20靶向免疫治疗有反应。本综述聚焦于儿童EBV+ PTLD的流行病学、EBV的作用、临床表现、当前治疗策略、过继性免疫治疗及未来研究。
Post-transplant Lymphoproliferative Disease (PTLD) remains a major complication of solid organ transplantation (SOT) in pediatric patients. The majority are Epstein-Barr Virus (EBV) driven CD20 + B-cell proliferations responsive to reduction to immunosuppression and anti-CD20 directed immunotherapy. This review focusses on the epidemiology, role of EBV, clinical presentation, current treatment strategies, adoptive immunotherapy and future research in EBV + PTLD in pediatric patients.
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