肿瘤细胞治疗研究
英文原题：Nodal peripheral T-cell lymphoma: Chemotherapy-free management, are we there yet?
外周T细胞淋巴瘤（PTCLs）是一组异质性较强且较为罕见的淋巴系统恶性肿瘤，预后极差。
外周T细胞淋巴瘤（PTCLs）是一组异质性且少见的淋巴系统恶性肿瘤，预后极差。近年来基因组研究的进展揭示了反复出现的突变，正在改变我们对本病分子遗传学和发病机制的认识。因此，目前正在探索新的靶向治疗和改善疾病结局的治疗方法。在本综述中，我们讨论了目前对结内PTCL生物学的认识及其潜在治疗意义，并就目前正在研究的有前景的新型疗法（如免疫治疗、CAR-T 细胞治疗和溶瘤病毒治疗）提出了我们的见解。
Peripheral T-cell lymphomas (PTCLs) are a diverse and uncommon type of lymphoid malignancies with a dismal prognosis. Recent advances in genomic studies have shown recurring mutations that are changing our knowledge of the disease's molecular genetics and pathogenesis. As such, new targeted therapies and treatments to improve disease outcomes are currently being explored. In this review, we discussed the current understanding of the nodal PTCL biology with potential therapeutic implications and gave our insights on the promising novel therapies that are currently under study such as immunotherapy, chimeric antigen receptor T-cell therapy, and oncolytic virotherapy.
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