肿瘤细胞治疗研究
英文原题：Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis.
尽管肾癌的免疫治疗已取得实质性进展，但其疗效因患者而异，许多患者反应欠佳甚至发生转移。
尽管肾癌免疫治疗已取得重大进展，但其疗效因患者而异，许多患者应答不佳甚至发生转移。因此，研究肿瘤免疫微环境和免疫细胞异质性对肾癌治疗至关重要。本研究利用透明细胞肾细胞癌（ccRCC）和正常肾组织单细胞测序数据中的特征基因分离自然杀伤（NK）细胞群体，并根据基因表达谱差异将其分为三个亚群：NK(GZMH)、NK(EGR1)和NK(CAPG)。基因集富集分析显示，NK(EGR1)和NK(CAPG)与肿瘤转移密切相关，表现为肾癌转移至霍奇金淋巴瘤、T细胞白血病和Ki-1+间变性大细胞淋巴瘤。因此，这两个NK细胞亚群是抑制ccRCC转移的有前景的靶点。我们的研究结果揭示了肾癌浸润NK细胞的异质性，可为肾癌转移机制提供参考。
Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney cancer treatment. In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). Gene set enrichment analysis revealed that NK(EGR1) and NK(CAPG) were closely related to tumour metastasis, as shown by kidney cancer metastasis to Hodgkin lymphoma, T-cell leukaemia, and Ki-1+ anaplastic large cell lymphoma. Thus, these two NK cell subpopulations are promising targets for inhibiting metastasis in ccRCC. Our findings revealed heterogeneity in the infiltrating NK cells of kidney cancer, which can serve as a reference for the mechanisms underlying metastasis in kidney cancer.
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