肿瘤细胞治疗研究
英文原题：Clinical, Diagnostic and Prognostic Characteristics of Primary Cutaneous Gamma Delta T-cell Lymphomas.
原发性皮肤γδ T细胞淋巴瘤（PCGDTL）是一种罕见的非霍奇金淋巴瘤（NHL）亚型，起源于具有γδ T细胞受体的T细胞。
原发性皮肤γδ T细胞淋巴瘤（PCGDTL）是一种罕见的非霍奇金淋巴瘤（NHL）亚型，起源于具有γδ T细胞受体的T细胞。PCGDTL的确切发病率尚不清楚，因为它通常与其他皮肤淋巴瘤归为一类，而后者同样不常见。它是外周T细胞淋巴瘤（PTCL）亚型之一，因治疗反应差且可用疗法匮乏，已知预后极差。尽管PCGDTL罕见且存在诸多不确定性，过去十年间已发表了大量关于该疾病病理学、诊断学、细胞遗传学和临床特征的研究。这些诊断学进展将为探索针对这一罕见实体的新疗法打开大门，尤其是靶向治疗和免疫治疗。在本综述中，我们重点介绍这些进展，总结当代治疗方法，并展望未来潜在的治疗靶点。
Primary cutaneous γδ T-cell lymphoma (PCGDTL) is a rare subtype of non-Hodgkin lymphoma (NHL) that arises from T-cells with γδ T-cell receptors. The exact incidence of PCGDTL is unknown, as it is usually lumped with other cutaneous lymphomas, which are also uncommon. It is one of the peripheral T-cell lymphoma (PTCL) subtypes which is known to have a dismal prognosis due to poor response and the paucity of available therapies. Despite the rarity and uncertainties of PCGDTL, a number of studies over the past decade were published about the pathologic, diagnostic, cytogenetic and clinical features of this disease. These diagnostic advances will open the doors to explore new therapeutics for this rare entity, specifically targeted and immune therapies. In this review, we highlight these advances, summarize the contemporary treatment approaches, and shed the light on future potential therapeutic targets.
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