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AML 中的 CD70 CAR-T 细胞:形式追随功能

英文原题:CD70 CAR T cells in AML: Form follows function.

PubMed 2022/05/17(内容时间) Cell Rep Med Q1 · IF 14(JCR 2025)

研究概要

采用多模态方法开发用于急性髓系白血病的新型 CD70 靶向嵌合抗原受体(CAR)T 细胞,Leick 等。

中文摘要

Leick等采用多模式方法开发靶向CD70的新型嵌合抗原受体(CAR)T细胞治疗急性髓系白血病;其报告的协同策略同时改造CAR-T细胞构建体并增强白血病抗原表达,以改善CAR-T细胞功能。

展开英文摘要原文

Using a multimodal approach toward developing a new CD70-targeted Chimeric antigen receptor (CAR) T cell in acute myeloid leukemia, Leick et al. 1 report on their synergetic strategy, which incorporates both CAR T cell construct modifications with enhancement of leukemia antigen expression to improve CAR T cell functionality.

论文信息

作者
Mirazee J、Shah NN
第一作者单位
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Johns Hopkins University Department of Biology, 3400 N. Charles Street, Baltimore, MD, USA.United States
通讯作者单位
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: nirali.shah@nih.gov.United States
文献类型
美国 NIH 院内研究 · 评论
期刊
Cell reports. Medicine2022 May 17
原文标识
PubMed 35584621 · DOI 10.1016/j.xcrm.2022.100639