肿瘤细胞治疗研究
英文原题：Global Research Trends on the Treatment of Diffuse Large B-Cell Lymphoma: A Bibliometric and Visualized Study.
2021 年 2 月 19 日从 WOSCC 共检索到 7,255 篇关于 DLBCL 治疗的研究。
弥漫性大B细胞淋巴瘤（DLBCL）是最常见的淋巴瘤亚型。近几十年来，DLBCL治疗取得显著进展，相关论文已发表数千篇。我们对DLBCL治疗文献进行文献计量分析，探讨作者、国家和机构之间的合作，并识别治疗研究热点。我们在Web of Science核心合集（WOSCC）中以“Diffuse Large B Cell Lymphoma或DLBCL”和“Treatment或Therapy或Clinical Trial”为主题词检索，并分析数据库提供的发表年份、研究方向、国家／地区、机构、作者、来源期刊、资助机构分布等信息。此外，使用科学计量学软件分析文献引用和合作发表情况，并通过bibliometric.com/app和VOSviewer进行分析。研究利用网络图评估作者、国家、机构和关键词之间的合作关系。截至2021年2月19日，共从WOSCC检索到7,255篇DLBCL治疗研究。1999至2021年间论文数量逐渐增加，过去3年相对稳定。发文量最多的国家为美国、中国和日本；机构中，德克萨斯大学MD安德森癌症中心发表论文最多。美国的年度发文量、引用量、期刊来源分布及资助数量也均居首位。国家间合作研究对DLBCL治疗同样十分重要。CHOP和R-CHOP等治疗方案以及CAR-T、PD-1／PD-L1、CAR-NK等免疫疗法受到越来越多关注。对DLBCL治疗研究开展文献计量分析，有助于研究人员和临床工作者快速了解该领域热点及发展趋势，并为公共卫生政策制定提供参考。
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype. Treatment of DLBCL has improved greatly in recent decades, with thousands of papers published. We conducted a bibliometric analysis of the literature on DLBCL treatment, and discussed cooperation among authors, countries, and institutions, and identified research hotspots for DLBCL treatment. We searched the Web of Science Core Collection (WOSCC) using "Diffuse Large B Cell Lymphoma or DLBCL" and "Treatment or Therapy or Clinical Trial" as the subject terms, and analyzed the publication year, research direction, country/region, institution, author, source publication, distribution of funding institutions, and other conditions provided by the database. In addition, scientometrics software was used to analyze literature citations and cooperative publications. Bibliometric analyses were performed using https://bibliometric.com/app and VOSviewer. Network maps were generated to evaluate collaborations between different authors, countries, institutions, and keywords. A total of 7,255 studies on treatment of DLBCL were retrieved from the WOSCC on February 19, 2021. We found that the number of publications increased gradually from 1999 to 2021, and this trend was relatively stable in the past 3 years. The countries that produced the most publications were the United States, China, and Japan. Among institutions, University of Texas MD Anderson Cancer Center published the most manuscripts. Furthermore, the United States also had the most annual publications, citations, distribution of journal sources, and funding. Cooperative research between countries is also relatively important to treatment of DLBCL. Therapeutic regimens such as CHOP and R-CHOP, and immunotherapy (CAR-T, PD1/PDL1, and CAR-NK, etc.), have received increased attention. Bibliometric analysis of studies related to DLBCL treatment can help researchers and clinical workers quickly understand the hotspots and development trends in this field, and provide reference for the formulation of public health policies.
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