肿瘤细胞治疗研究
英文原题：Polymeric Systems for Cancer Immunotherapy: A Review.
免疫疗法通过激活免疫系统消除肿瘤，为开创癌症治疗的新局面带来了巨大希望。
免疫疗法通过激活免疫系统清除肿瘤，有望为癌症治疗带来新局面。聚合物系统在提高免疫疗法抗肿瘤效力和安全性方面发挥重要作用。聚合物系统具有多种有利特性，包括优异的生物相容性和可降解性、结构及组成多样、易于可控制备，以及具有较高免疫相关物质负载能力。因此，聚合物系统可在免疫治疗中发挥多种功能，例如作为免疫刺激剂、修饰和活化T细胞、递送免疫活性物质，或用作人工抗原呈递细胞。在多种免疫疗法中，免疫检查点抑制剂、嵌合抗原受体（CAR）T细胞和溶瘤病毒因临床试验取得显著成功而近期受到广泛研究。本文综述免疫检查点抑制剂、CAR-T细胞和溶瘤病毒单药治疗的现状，以及它们与不同聚合物系统联合应用的当前策略。
Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.
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