研究概要
在本期Cell Stem Cell中,Woan等人(2021)研究了三基因编辑的iPSC衍生自然杀伤(NK)细胞的抗癌活性,并证明表达修饰的CD16a和白细胞介素(IL)-15受体结合CD38敲除可增强NK细胞介导的抗白血病和多发性骨髓瘤活性。
中文摘要
在本期Cell Stem Cell中,Woan等人(2021)研究了三基因编辑的iPSC衍生自然杀伤(NK)细胞的抗癌活性,并证明表达修饰的CD16a和白细胞介素(IL)-15受体结合CD38敲除可增强NK细胞介导的抗白血病和多发性骨髓瘤活性。
展开英文摘要原文
In this issue of Cell Stem Cell, Woan et al., (2021) investigate the anti-cancer activity of triple gene edited iPSC-derived natural killer (NK) cells and demonstrate that expression of a modified CD16a and interleukin (IL)-15 receptor combined with knockout of CD38 improves NK cell-mediated activity against leukemia and multiple myeloma.
论文信息
- 作者
- Goldenson BH、Kaufman DS
- 第一作者单位
- Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA.United States
- 通讯作者单位
- Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: dskaufman@ucsd.edu.United States
- 文献类型
- 评论
- 期刊
- Cell stem cell2021 Dec 2