肿瘤细胞治疗研究
英文原题：Primary mediastinal large B cell lymphoma.
Primary mediastinal large B cell lymphoma.
原发性纵隔大 B 细胞淋巴瘤（PMBCL）是一种起源于纵隔的侵袭性大 B 细胞淋巴瘤，主要表达 B 细胞表面分子，如 CD19、CD20、CD22 和 CD79a。
原发性纵隔大B细胞淋巴瘤（PMBCL）是一种起源于纵隔的侵袭性大B细胞淋巴瘤，主要表达CD19、CD20、CD22和CD79a等B细胞表面分子。临床上常表现为迅速增大的前纵隔肿块，可压迫周围组织。PMBCL诊断主要依据病理特征、影像学检查和临床表现。目前最常用的治疗方案为R-CHOP和R-EPOCH。放疗对部分患者有益，但也可能造成长期毒性。新疗法仍在研发中，部分研究已取得令人鼓舞的结果，包括嵌合抗原受体修饰T细胞（CAR-T）疗法和抗PD-1药物。不过，仍需样本量更大的随机对照试验。正电子发射断层扫描-计算机断层扫描（PET-CT）主要用于评估治疗后的疗效并指导后续治疗策略。
Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive large B cell lymphoma originating in the mediastinum, that mainly expresses B cell surface molecules, such as CD19, CD20, CD22, andCD79a. Clinically, they are characterized by rapidly increasing anterior mediastinal masses, which can cause compression of the surrounding tissues. The diagnosis of PMBCL mainly depends on the pathological features, imaging examination and clinical features. Currently, the most commonly used therapeutic regimens are R-CHOP and R-EPOCH. Radiotherapy is beneficial in some patients, but it can also lead to long-term toxicity. The research and development of novel therapies are ongoing, and some studies have achieved encouraging results, including those conducted on chimeric antigen receptor-modified T (CAR-T) cell therapy and anti-PD-1 drugs. However, randomized controlled trials with larger sample sizes are still needed. Positron emission tomography-computed tomography (PET-CT) is mainly used to assess the curative effect after treatment and to guide the subsequent treatment strategy.
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