联合免疫治疗驱动小鼠肾肿瘤微环境中肿瘤抗原特异性 CD8⁺ T 细胞耗竭

Combinatorial immunotherapy drives exhaustion in tumor antigen-specific CD8+ T cells within the mouse renal tumor microenvironment.

VHL 与 DNA 损伤修复通路改变作为转移性透明细胞肾细胞癌一线 TKI 的潜在临床生物标志物

VHL and DNA damage repair pathway alterations as potential clinical biomarkers for first-line TKIs in metastatic clear cell renal cell carcinomas.

我们发现，携带 DDR 和 VHL 改变的 mccRCC 患者比野生型患者更可能从一线 VEGF-TKI 系统性治疗中获益。

通过患者来源的离体模型对肾细胞癌肿瘤免疫微环境进行功能性表征

Functionally Characterizing the Renal Cell Carcinoma Tumor-Immune Microenvironment via Patient-Derived Ex Vivo Models.

转移性透明细胞肾细胞癌的治疗管理：每十年一次的革命

Therapeutic Management of Metastatic Clear Cell Renal Cell Carcinoma: A Revolution in Every Decade.