通过 CD39 下调增强 CAR T 细胞功能与代谢
Augmenting CAR T cell functionality and metabolism through CD39 downtuning.
CD39/CD73轴是T细胞功能的有效内在抑制因子。
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Augmenting CAR T cell functionality and metabolism through CD39 downtuning.
CD39/CD73轴是T细胞功能的有效内在抑制因子。
Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer
我们的研究支持新辅助 Io+Chemo 优于 Chemo,并揭示 Io+Chemo 可诱导形成免疫激活的微环境,从而使 Io+Chemo 优于 Chemo。
Impact of Mutations in Subunit Genes of the Mammalian SWI/SNF Complex on Immunological Tumor Microenvironment.
这些结果提示,免疫肿瘤微环境状态,例如以TLS基因特征为特点的成熟B细胞募集,以及由癌症信号下调介导的免疫激活,可能有助于将SMARCA4基因突变肿瘤归类为免疫检查点阻断治疗敏感的靶向肿瘤。
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