用于乳腺癌治疗的可注射水凝胶:从肿瘤微环境响应性与主动靶向药物递送到免疫治疗与诊疗一体化
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
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Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma.
头颈部鳞状细胞癌(HNSCC)仍是最具侵袭性的恶性肿瘤之一,治疗选择有限,尤其是在复发和转移性病例中。
Supramolecular peptide hydrogel epitope vaccine functionalized with CAR-T cells for the treatment of solid tumors.
CAR-T 细胞疗法得益于基因编辑技术与抗体工程的完美结合,在血液系统恶性肿瘤中展现出卓越的临床疗效。
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.
NR4A因子通过线粒体基因表达调控CAR-T细胞的持久性和干性,因此NR4A是生成针对实体瘤的优质CAR-T细胞的高度有前景的靶点。
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
实体瘤的嵌合抗原受体(CAR)-T 细胞疗法面临重大障碍,包括由 PD-1/PD-L1 轴介导的 T 细胞抑制。
Chimeric antigen receptor T cell therapy for glioblastoma: overcoming current barriers and strategies to enhance efficacy for therapeutic implications
胶质母细胞瘤(GBM)是一种高度恶性的原发性脑肿瘤,其特点是治疗选择有限且生存结局差。
HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity.
我们已在临床前验证了一种 iCAR NOT 门控技术,该技术广泛适用于在 A2 LOH 背景下靶向 HER2 表达。
Gain-of-function enhancers optimize CAR-NK cell-based anti-cancer immunotherapy.
用于识别NK细胞适应性基因的两阶段筛选方法示意图。
CAR-T cell therapy in breast cancer management: expanding horizon and overcoming challenges beyond hematologic cancers.
乳腺癌(BC)仍然是发病率最高、治疗最具挑战性的癌症之一,目前的治疗方法往往受到治疗耐药和不良反应的限制。
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment.
RB-312 是首个临床相关的产品,整合了 CRISPRa 系统,实现非基因编辑且可逆地上调内源性基因表达,从而促进 CAR-T 细胞的持久性并增强对表达 HER2 肿瘤的疗效。
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